Health and wellness – Sharpless, Bertozzi and Meldal: click chemistry and bioorthogonal at the service of health

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The 2022 Nobel Prize in Chemistry has been awarded to Dane Morten Meldal and to Americans Carolyn Bertozzi and Barry Sharpless. The trio of scientists was recognized for the development of click chemistry and bioorthogonal chemistry, which are revolutionizing the field of health.

It’s called click (or click) chemistry and in the words of the Swedish academy, it is “an elegant and efficient reaction that is currently widely used.” …“among many other uses, it is used in the development of pharmaceutical products, DNA mapping and the creation of new materials”, the jury concluded.

the dane Morten Meldala 58-year-old from the University of Copenhagen and the American Barry Sharpless who works for the Scripps Research Institute in La Jolla California, were recognized for their pioneering work with click chemistry, a new way of combining molecules. Barry Sharpless, 81 years old, already has a Nobel Prize in Chemistry that was awarded to him in 2001.

On October 5, the 2022 Nobel Prize in Chemistry was awarded to three scientists, the Americans Carolyn Bertozzi and Barry Sharpless and the Dane and Morten Meldal. © AP/Christine Olsson

bioorthogonal chemistry

For its part, the American Carolyn Bertozzi55, is a professor at Stanford University and was awarded for the development of bioorthogonal chemistry, a chemical reaction that is described as capable of being initiated in a living organism but without disturbing its chemical nature.

These two types of chemistry can contribute much to health, such as the development of future cancer treatments.

The Curie Institutefounded by Marie Curie herself in 1921, is a research center specializing in cancer treatment and is very pleased with this Nobel Prize, since click chemistry and bioorthogonal chemistry are a technique used in the Chemistry and Doctor’s Cell Biology Raphaël Rodriguez to label and visualize any biologically active small molecule, i.e. live.

Tatiana Caneque He works in this laboratory as a research engineer and explained to RFI the importance of this Nobel Prize in Chemistry and its applications, especially in the field of health.

Listen to the interview here:

MAG SALUD 2022_10_27 NOBEL PRIZE CHEMISTRY CLICK AND BIOORTOGONAL antenna f/v 12’25”

Click chemistry, developed by Meldal and Sharplessit is called that because it is often compared to a set of Legos, as if only two bricks in a cell could fit together, make “click”.

Bioorthogonal chemistry, developed by Bertozzimanages to cause this click reaction, but in a living organism, without disturbing its chemical nature and incorporating a visible one thanks to a fluorescent substance that the scientist will use in the functional groups of the molecules.

Thanks to these discoveries, it has been possible to develop, in addition to innovative cancer treatments, other applications such as being able to administer treatments with extreme precision, better understand how drugs work inside the body or visualize certain bacteria.

English video of Carolyn Bertozzi explaining bioorthogonal chemistry:


And in this TEDx Stanford talk, also in English, Carolyn Bertozzi explains in a very entertaining way the role of the cells’ sugar coat and how it relates to innovative treatments to fight cancer cells:


We would love to give thanks to the writer of this post for this amazing material

Health and wellness – Sharpless, Bertozzi and Meldal: click chemistry and bioorthogonal at the service of health